TABLE 4.
Cytokine concentrations in plasma of APAP-treated HIF-1α+fl/+fl and HIF-1αΔ/Δ mice
HIF-1α+fl/+fl and HIF-1αΔ/Δ mice were treated with SAL or APAP, and plasma was collected 6 h after administration and analyzed for cytokine concentrations using bead array.
| Cytokine | Plasma Cytokine |
|||
|---|---|---|---|---|
| SAL |
APAP |
|||
| HIF-1α+fl/+fl | HIF-1αΔ/Δ | HIF-1α+fl/+fl | HIF-1αΔ/Δ | |
| pg/ml | ||||
| Interferon-γ | 15.9 ± 1.0 | 17.3 ± 1.4 | 17.4 ± 1.5 | 17.6 ± 0.5 |
| IL-1β | 6.1 ± 0.5 | 6.2 ± 0.3 | 6.9 ± 0.6 | 6.5 ± 0.5 |
| IL-2 | 4.0 ± 0.4 | 3.8 ± 0.2 | 5.8 ± 0.9 | 4.4 ± 0.3 |
| IL-4 | 4.8 ± 0.3 | 5.0 ± 0.5 | 4.5 ± 0.4 | 4.2 ± 0.3 |
| IL-6 | 23.5 ± 3.0 | 27.8 ± 3.7 | 231 ± 45.1a | 38.2 ± 5.6b |
| IL-10 | 10.9 ± 0.4 | 11.6 ± 0.4 | 14.0 ± 1.4 | 11.5 ± 0.2 |
| IL-12 (p70) | 14.8 ± 0.6 | 15.4 ± 0.2 | 14.6 ± 0.5 | 14.4 ± 0.3 |
| KC (mIL-8) | 49.8 ± 7.4 | 40.3 ± 8.0 | 573 ± 372a | 110 ± 25.5b |
| MIP-1α | 11.5 ± 0.5 | 12.1 ± 0.3 | 12.4 ± 0.7 | 12.0 ± 0.3 |
| RANTES | 28.5 ± 4.0 | 27.3 ± 1.5 | 52.9 ± 10.9a | 33.2 ± 3.2b |
| TNFα | 17.9 ± 0.4 | 18.4 ± 0.5 | 20.0 ± 1.0 | 18.3 ± 0.4 |
| VEGF | 19 ± 0.4 | 20.5 ± 0.6 | 19.1 ± 0.6 | 19.5 ± 0.6 |
a
Significantly different from SAL-treated HIF-1α+fl/+fl mice.
b
Significantly different from APAP-treated HIF-1α+fl/+fl mice.