Fig. 2.

Cocaine does not inhibit dopamine uptake in the NAc of DAT-KO mice. The effects of cocaine (0.1, 1, and 3 mM) locally applied in the NAc on extracellular concentrations of dopamine in wild-type (○) and DAT-KO (•) mice are shown. Arrows represent the time of administration of each different concentration of cocaine through the microdialysis probe located in the NAc area. Data are mean ± SEM values from four to five separate animals for each group and are expressed as percentages of the corresponding basal value.