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. 2011 Jul 5;108(29):12107–12112. doi: 10.1073/pnas.1109718108

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Fig. 5. — D2R overexpression in the striatum desensitizes the effect of the D2 agonist on both IPSCs and EPSCs. Representative traces showing evoked IPSCs (A) and EPSCs (B) recorded from control and D2R-OE mice before and after application of the D2 agonist quinpirole (10 μM). Quinpirole significantly decreased the amplitude of the first IPSCs (C, n = 6, *P < 0.05) but increased the amplitude of EPSCs (D, n = 6, *P < 0.05) in control mice. In contrast, quinpirole exhibited no effects on the amplitudes of both evoked IPSCs and EPSCs in D2R-OE mice (C and D, n = 6, P = 0.24). We did not observe any significant changes in subsequent IPSCs (E) and EPSCs (F) in the trains before and after application of quinpirole, indicating unaltered paired-pulse ratios in both IPSC and EPSC (n = 6, P > 0.05 for all by ANOVA).