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. 2011 Jun 28;108(29):11848-11853. doi: 10.1073/pnas.1102664108

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Fig. 4. — MS¹ and CID MS² of APP/AβX-15 glycopeptides. (A) Amino acid sequence of APP/AβX-15, where X = -63, −57, −51, and −25. Underlined residues show Thr(−39, −21, −20, and −13) glycosylation sites. Either Ser(−5) or Thr(−9) was glycosylated (dashed underlines). The b9, b15, b21, and y57 fragmentation site is indicated. (B) CID MS² of triglycosylated APP/Aβ−25-15 showing neutral loss of Neu5Ac from the glycopeptide. (C) Triglycosylated APP/Aβ−51-15 with diagnostic b9 (m/z 987.4) and glycosylated y57 fragment ions. (D) Triglycosylated APP/Aβ−57-15 with diagnostic b15 (m/z 835.0) and glycosylated y57 fragments. (E) Tetraglycosylated APP/Aβ−63-15 with a diagnostic b21 fragment (m/z 1,151.5).