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. 2011 Jul 5;108(29):11924–11929. doi: 10.1073/pnas.1103418108

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Fig. 2. — Loss of Ezrin disrupts the formation of apical membrane complexes. (A) BBs were isolated from control (lanes 1 and 3) and Ez^−/− (lanes 2 and 4) small intestines. Total cell lysate (TCL) and BB fractions were solubilized in the presence of 1% SDS. Villin served as a positive control for the BB fraction and aminopeptidase N (APN), and Crumbs3 served as controls for apical membrane proteins. Note the specific loss of NHERF1 and Slk in Ez^−/− BBs. (B and C) NHERF1 is apically concentrated in colonic epithelia from tamoxifen-treated Ez^lox/lox (control, B), but not Vil-Cre-ER^T2;Ez^lox/lox (Ez^−/−, C) mice.