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NPM-ALK promotes epigenetic silencing of the IL-2Rγ gene. (A) Effect of the siRNA-mediated NPM-ALK depletion on expression of IL-2Rγ. (B) Dose-dependent effect of small-molecule ALK inhibitor on IL-2Rγ expression. (C) Effect of the enforced NPM-ALK expression on expression of IL-2Rγ protein and methylation status of the IL-2Rγ gene promoter.
