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. 2011 Jun 29;108(29):11977–11982. doi: 10.1073/pnas.1100319108

Fig. 5.

Fig. 5.

STAT3 inhibits miR-21 expression and miR-21 selectively inhibits DNMT1 RNA expression. (A) Kinetics of the STAT3 siRNA-induced miR-21 expression detected by the DNA oligonucleotide array. The data are depicted as fold increase in the miR-21 mRNA expression in the STAT3 siRNA-treated compared with the control siRNA-treated cells. (B) Schematic representation of the miR-21 binding sites in 3′-UTR of DNMT1 mRNA and the sequence complementarity of miR-21 and the DNMT1 3′-UTR target sequence. (C) STAT3 siRNA-induced miR-21 expression detected by qRT-PCR. (D) Binding of STAT3 to the miR-21 promoter in vivo detected by ChIP. (E) Effect of miR-21 on expression of members of the DNMT family detected by RT-qPCR.