TABLE 1.

NOD-Ncf1^m1J CD8⁺ T cells exhibit a decrease in synthesis of the proinflammatory cytokine IFN-γ and the cytotoxic effector molecule granzyme B. Proliferation by [³H]TdR incorporation and intracellular cytokine staining for CD8⁺/IFN-γ⁺ and CD8⁺/GzmB⁺ after 72-h stimulation of purified naïve CD8⁺ T cells from the spleen of NOD and NOD-Ncf1^m1J mice

	NOD	NOD-Ncf1m1J
CPM	20,080 ± 2,668a	35,260 ± 4,472b
CD8+/IFN-γ+ (%)	31.05 ± 1.29c	22.65 ± 1.91d
CD8+/GzmB+b (%)	77.34 ± 7.05e	60.68 ± 7.52f

Data are means ± SD. CPM, counts per minute.

P = 0.014 for a vs. b; P = 0.0003 for c vs. d; P = 0.011 for e vs. f.