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SOCS1 LysM-Cre mice have increased sensitivity to LPS and palmitate, Tnfa (A and D), Il6 (B and E), and Il1b (C and F) measured by RT-quantitative PCR after stimulation of bone marrow–derived macrophages from wild-type and SOCS1 LysM-Cre mice with increasing concentrations of LPS and palmitate, respectively. Data are means ± SEM; n = 3 per group. White bars, FL/FL control mice; black bars, SOCS1 LysM-Cre mice. *P < 0.05 genotype effect relative to control.
