TABLE 3.
Parameters of pulsatile insulin and glucagon secretion after ingestion of a mixed test meal
| Parameter (unit) | Type 2 diabetes | Controls | P value |
|---|---|---|---|
| Insulin | |||
| Pulse interval (min) | 5.3 ± 0.5 | 5.1 ± 0.5 | 0.62 |
| Pulse mass (mU ⋅ L−1 ⋅ pulse−1) | 7.7 ± 1.0 | 21.5 ± 3.3 | 0.008 |
| Nonpulsatile secretion (mU ⋅ L−1 ⋅ min−1) | 2.4 ± 0.4 | 3.0 ± 0.8 | 0.54 |
| ApEn | 1.19 ± 0.03 | 1.31 ± 0.03 | 0.019 |
| Contribution of pulsatile secretion (%) | 85.8 ± 2.9 | 93.3 ± 3.0 | 0.087 |
| Glucagon | |||
| Pulse interval (min) | 4.7 ± 0.4 | 6.6 ± 0.6 | 0.11 |
| Pulse mass (pmol ⋅ L−1 ⋅ pulse−1) | 8.1 ± 0.9 | 5.9 ± 0.6 | 0.035 |
| Nonpulsatile secretion (pmol ⋅ L−1 ⋅ min−1) | 1.1 ± 0.29 | 0.53 ± 0.20 | 0.13 |
| ApEn | 1.23 ± 0.03 | 1.27 ± 0.04 | 0.38 |
| Contribution of pulsatile secretion (%) | 94.7 ± 1.6 | 93.0 ± 2.8 | 0.62 |
Data are means ± SEM. P values were calculated using unpaired Student t test.