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NOD/ShiLtJ mice showed no decline in arginine-stimulated insulin secretion from 6 to 14 weeks of age. There was no significant change in insulin levels over time (A) (P = 0.32), change from baseline to 2 min (B) (P = 0.73), or change in AUC from 0 to 5 min (C) (P = 0.79) or from 0 to 10 min (D) (P = 0.89). n = 5 mice per group. Data are presented as mean ± SEM after intraperitoneal administration of l-arginine (1 g/kg body weight).
