FIG. 2.
Effect of Ncx1 heterozygous inactivation on glucose-induced insulin release and [Ca2+]i oscillations. Effect of 11.1 mmol/L glucose on insulin release (A and B) and [Ca2+]i (C and D) from groups of 20 islets: representative experiment (A), mean of four (Ncx1+/+) and six (Ncx1+/−) individual experiments (B). C and D show typical individual traces observed in Ncx1+/+ and Ncx1+/− islets, respectively. The curves are representative of seven and eight individual traces, respectively. The period of exposure to glucose 11.1 mmol/L is indicated by a bar above the curves. In both cases, the islets were from different mice. E and F present the same traces as in panels C and D, showing the [Ca2+]i oscillations between min 14 and 16 on a larger scale. G and H: Power spectral analysis of the oscillations observed in typical individual traces. (A high-quality digital representation of this figure is available in the online issue.)