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. 2011 Jul 18;60(8):2076–2085. doi: 10.2337/db10-0924

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© 2011 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 6. — Effect of Ncx1 heterozygous inactivation on islets transplantation and glucose metabolism is shown in vivo. Effect of transplanting grafts of 100 islets from Ncx1^+/+ (A) or Ncx1^+/− (B) mice is shown on nonfasting blood glucose levels. The success rate of diabetes cure (blood glucose level <220 mg/dL) was 2/5 for Ncx1^+/+ and 4/5 for Ncx1^+/− islets. Nephr, nephrectomy. C and E: Glycemia and insulin levels measured in the fasting and the fed state of Ncx1^+/+ and Ncx1^+/− mice (n = 5 in each case). D and F: Glycemia and insulin levels are shown during an intraperitoneal glucose tolerance test in Ncx1^+/+ and Ncx1^+/− mice (n = 8 in each case). *P < 0.05. Data are shown as the means ± SEM.

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