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. 2011 Jul 18;60(8):2179–2186. doi: 10.2337/db10-1210

FIG. 3.

FIG. 3.

Effects of rh-sCD14 on insulin action and glucose turnover. A: Glucose turnover rates (mg/kg/min) of WT and CD14 KO mice infused with rh-sCD14 or saline during a hyperinsulinemic glucose clamp (n = 6–8 mice per group). *P < 0.05 for sCD14 vs. saline treatment, using Student t test. Effects of rh-sCD14 (n = 9) or vehicle (n = 9) in high fat–fed mice on (B) fasting glucose and insulin concentrations and (C) glucose after IPGTTs. Glucose (2 g/kg) was injected intraperitoneally after an overnight fast. Effects of treatment with rh-sCD14 or vehicle in ob/ob mice on body weight (D), fasting glucose and insulin concentrations (n = 4–5) (E), and IPGTT (F). Dashed line, mice treated with vehicle; continuous line, mice treated with rh-sCD14. G: Glucose/insulin ratio. Two-way ANOVA test indicated a significant difference between the glucose (P = 0.002) and insulin (P < 0.0001) curves of sCD14- and vehicle-treated mice. *P < 0.05 for sCD14 vs. vehicle treatment, using Student t test. (A high-quality color representation of this figure is available in the online issue.)