Table 2. Genetic determination of sPLA2-IIa concentrations.
| Genotypic model (three-categorical) | Additive model | ||||||||||
| Single nucleotide polymorphism (n) | Common/ rare allele | Minor allele frequency | P χ2(HWE) | R2 | P*a | Δ%b | (95% CI) | Δ%c | (95% CI) | Δ%d | (95% CI) |
| rs10799599 (995) | C/G | 0.37 | 0.23 | 0.049 | <0.0001 | −20.3 | (−28.6 to −11.0) | −44.8 | (−53.2 to −34.8) | −24.2 | (−29.8 to −18.2) |
| rs876018 (989) | A/T | 0.15 | 0.52 | 0.008 | 0.047 | −15.6 | (−25.3 to −4.5) | 2.5 | (−26.7 to 43.3) | −10.3 | (−19.1 to −0.5) |
| rs955587 (994) | C/T | 0.12 | 0.01 | 0.007 | 0.0095 | −8.3 | (−19.2 to 4.2) | −44.1 | (−71.9 to 11.2) | −10.3 | (−20.5 to 1.2) |
| rs4744 (996) | G/A | 0.23 | 0.21 | 0.158 | <0.0001 | 87.6 | (69.4 to 107.8) | 199.8 | (138.1 to 277.6) | 81.3 | (66.9 to 96.9) |
| rs10732279 (1008) | T/C | 0.26 | 0.33 | 0.148 | <0.0001 | 77.2 | (60.1 to 96.2) | 186.5 | (133.3 to 251.8) | 73.3 | (60.0 to 87.6) |
| rs3753827 (1007) | C/A | 0.44 | 0.83 | 0.033 | <0.0001 | −24.7 | (−33.1 to −15.2) | −36.1 | (−45.0 to −25.7) | −20.6 | (−26.3 to −14.5) |
| rs11573156 (1001) | G/C | 0.25 | 0.04 | 0.160 | <0.0001 | 90.0 | (71.8 to 110.1) | 188.1 | (129.3 to 262.0) | 81.1 | (66.8 to 96.6) |
| rs10916685 (995) | A/T | 0.34 | 0.46 | 0.015 | 0.0015 | −17.1 | (−25.9 to −7.2) | −27.1 | (−38.6 to −13.5) | −15.4 | (−21.7 to −8.5) |
| rs818678 (984) | C/T | 0.39 | 0.88 | 0.013 | 0.0002 | −12.0 | (−21.6 to −1.3) | −26.1 | (−37.0 to −13.3) | −13.6 | (−19.9 to −6.8) |
a
Based on non-parametric Kruskal-Wallis test on untransformed sPLA2-IIa concentrations.
b
Percent change in geometric mean sPLA2-IIa concentration in heterozygotes in reference to common homozygotes.
c
Percent change in geometric mean sPLA2-IIa concentration in rare homozygotes in reference to common homozygotes.
d
Percent change in geometric mean sPLA2-IIa concentration per minor allele present.
Genotype distributions, proportion of variance in ln-transformed sPLA2-IIa serum concentration explained by the SNPs studied (R2; one-way ANOVA), and results from age- and sex-adjusted regression models predicting ln-transformed sPLA2-IIa concentrations from genotypes.