Table 4. Observed and expected relative risks.
| Genotype | HRa | (95% CI) | HRb | (95% CI) | ||
| Observed associations | rs10799599 | CC | 1 | ref. | 1 | ref. |
| CG | 0.88 | (0.62–1.23) | 0.85 | (0.67–1.09) | ||
| GG | 0.71 | (0.40–1.24) | ||||
| rs876018 | AA | 1 | ref. | 1 | ref. | |
| AT | 1.24 | (0.87–1.78) | 1.11 | (0.82–1.50) | ||
| TT | 0.76 | (0.24–2.40) | ||||
| rs4744 | GG | 1 | ref. | 1 | ref. | |
| GA | 1.09 | (0.77–1.53) | 1.16 | (0.89–1.51) | ||
| AA | 1.52 | (0.79–2.93) | ||||
| rs10732279 | TT | 1 | ref. | 1 | ref. | |
| TC | 1.04 | (0.74–1.46) | 1.18 | (0.91–1.52) | ||
| CC | 1.65 | (0.94–2.93) | ||||
| rs3753827 | CC | 1 | ref. | 1 | ref. | |
| CA | 0.71 | (0.50–1.02) | 0.89 | (0.71–1.13) | ||
| AA | 0.87 | (0.56–1.35) | ||||
| rs10916685 | AA | 1 | ref. | 1 | ref. | |
| AT | 0.83 | (0.59–1.17) | 0.91 | (0.72–1.16) | ||
| TT | 0.92 | (0.55–1.54) | ||||
| rs818678 | CC | 1 | ref. | 1 | ref. | |
| CT | 1.03 | (0.72–1.47) | 1.03 | (0.81–1.30) | ||
| TT | 1.06 | (0.65–1.74) | ||||
| Expected associations | rs4744 | GG | 1 | ref. | 1 | ref. |
| GA | 1.20 | (1.05–1.37) | 1.18 | (1.05–1.34) | ||
| AA | 1.37 | (1.09–1.74) | ||||
| rs10732279 | TT | 1 | ref. | 1 | ref. | |
| TC | 1.18 | (1.05–1.33) | 1.17 | (1.05–1.31) | ||
| CC | 1.35 | (1.09–1.70) |
a
Genotypic model (three-categorical), adjusted for age and sex.
b
Additive genotype model, adjusted for age and sex.
Observed associations of individual SNPs with secondary cardiovascular events (hazard ratios [HR] from Cox regression), and effects expected by Mendelian randomization if the fully adjusted ln[sPLA2-IIa] association of HR (95% CI) = 1.33 (1.09–1.63) is not due to confounding.