Figure 3. Effect of CysLT₁ receptor antagonists, montelukast, pranlukast, and zafirlukast, on UDP-evoked I_SC responses.

Representative recordings of I_SC in response to the apical application of 100 µM UDP (shown by arrows) in the presence of montelukast (A). The CysLT₁ receptor antagonist was applied 10 min before the application of UDP (data not shown). Data are summarized for the inhibitory effects of montelukast (B) on the first and second peaks of I_SC increases in response to UDP. Similar experiments were performed using pranlukast (C and D) or zafirlukast (E and F). The control was the apical application of UDP alone in the absence of any CysLT₁ receptor antagonist. Each column represents the mean ± S.E. (n = 4–5). (*, p<0.05, one-way ANOVA with Bonferroni post-hoc test compared with control).