Figure 5.

The caspase-8 inhibitor, IETD, only partially blocks cell death induced by MiTMABs. A-D, G₂/M synchronized HeLa cells were treated with MiTMABs and controls as described in the legend to Figure 2, except that the caspase-8 inhibitor, IETD, was used instead of ZVAD. Representative flow cytometry histograms of HeLa cells treated with MiTMABs in the presence (filled histograms) and absence (empty histograms) of IETD are shown (A). Quantitation (mean ± S.D.) of cells containing <2N (B), 4N (C) and >4N (D) DNA contents were determined from two independent experiments. * p < 0.05, ** p < 0.01 (Student's t tests).