Table 2.
Exposure to maternal-fetal composite Rh/ABO incompatibility and regional volumetric brain outcomes in subjects with schizophrenia or other schizophrenia spectrum disorder
| Brain region/structure | Volume (cm3) | P-value from Gamma modelA | |||
|---|---|---|---|---|---|
| Exposed case subjects (n=4) | Unexposed case subjects (n=15) | ||||
| Mean | SD | Mean | SD | ||
| Cortical Gray Matter | 632.54 | 59.65 | 657.45 | 72.43 | .0164 |
| Dorsolateral Prefrontal Cortex Left | 11.87 | 1.38 | 13.87 | 2.14 | .0235 |
| Dorsolateral Prefrontal Cortex Right | 12.07 | 1.84 | 14.50 | 1.61 | .0017 |
| Orbitofrontal Cortex Left | 22.04 | 3.83 | 20.57 | 4.29 | .6132 |
| Orbitofrontal Cortex Right | 20.84 | 3.58 | 21.21 | 3.35 | .5677 |
| Inferior Frontal Cortex Left | 9.98 | 1.32 | 11.25 | 1.65 | .0266 |
| Inferior Frontal Cortex Right | 10.26 | 1.73 | 11.32 | 1.32 | .0436 |
| Superior Temporal Gyrus Left | 13.27 | 2.16 | 13.97 | 1.41 | .1214 |
| Superior Temporal Gyrus Right | 13.47 | 1.87 | 14.07 | 1.81 | .2084 |
| Ventricular CSF | 33.98 | 16.42 | 31.11 | 12.86 | .8204 |
| Sulcal CSF | 207.86 | 72.84 | 164.25 | 40.35 | .0739 |
| Subcortical Gray Matter | 4.19 | 1.64 | 3.61 | 1.70 | .5577 |
| Total Hippocampus LeftB | 3295.08 | 441.15 | 3376.31 | 385.51 | .6951 |
| Total Hippocampus RightB | 3772.96 | 420.89 | 3799.44 | 522.61 | .9497 |
| Caudate Left | 4.87 | 0.27 | 5.09 | 0.56 | .1534 |
| Caudate Right | 5.09 | 0.54 | 5.11 | 0.53 | .5136 |
| Putamen Left | 5.21 | 0.58 | 5.54 | 0.74 | .2124 |
| Putamen Right | 5.36 | 0.34 | 5.62 | 0.82 | .3286 |
| Thalamus Left | 6.53 | 0.77 | 6.72 | 0.80 | .3895 |
| Thalamus Right | 6.45 | 0.80 | 6.85 | 0.77 | .0922 |
| White Matter | 589.01 | 33.93 | 571.74 | 71.92 | .6161 |
| Intracranial | 1502.78 | 166.05 | 1463.26 | 172.71 | .6688C |
A
Adjusted for intracranial volume (cm3)
B
Measured in mm3
C
P value without adjustment for intracranial volume