Skip to main content
. Author manuscript; available in PMC: 2011 Jul 23.
Published in final edited form as: Adv Virus Res. 2010;78:87–142. doi: 10.1016/B978-0-12-385032-4.00003-3

FIGURE 2.

FIGURE 2

KSHV primary infection and the cell signaling pathways targeted. Infection is initiated by cell fusion or endocytosis. For cell fusion, KSHV fuses with the plasma membrane by gB, gH, gL, gM, gN, and gpK8.1A, then release of virus particles to the cell plasma. For endocytosis, KSHV binds to the cell surface via interactions with heparan sulfate (HS) followed by temporal interactions with integrins and xCT (CD98) molecules, then formation of endocytic vesicles, virus entry, movement in the cytoplasm, release of virus particles, delivery into the nucleus by dynein along the microtubule. Viral gene expression interferes with the cellular signaling pathways such as MAPK, JAK–STAT, Notch, HIF, Wnt, and miRNA, consequently reprograms host cell gene expression.