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. Author manuscript; available in PMC: 2011 Jul 23.
Published in final edited form as: Adv Virus Res. 2010;78:87–142. doi: 10.1016/B978-0-12-385032-4.00003-3

TABLE 2.

Major cellular homologs encoded by KSHV

Gene product ORF Function Expression pattern
vIL-6 K2 Constitutively activate gp130 independently of IL-6R; B cell proliferation; auto/paracrine growth factors; angiogenic Productive
vCCL1 K6 CCR5 and CCR8 agonists; chemoattraction of Th2 cells and monocytes; angiogenic Productive
vCCL2 K4 CCR3 and CCR8 agonists; chemoattraction of Th2 cells and monocytes; angiogenic Productive
vCCL3 K4.1 CCR4 agonist; chemoattraction of Th2 cells; induction of VEGF-A and angiogenesis Productive
vIAP K7 Inhibitor of apoptosis; inhibition of vGPCR expression and function Productive
vBcl-2 ORF16 Inhibition of Bax-mediated and virally induced apoptosis Productive
vIRF1 K9 Transformation; inhibition of p300, p53, and TGF-β; inhibition of type I interferon Productive
vIRF2 K11.5 Inhibition of type I interferon and NF-kB; inhibition of Fas-mediated apoptosis via inhibition of CD95L expression Productive
LANA-2 K10.5 Inhibition of type I interferon production; inhibition of PKR- and caspase 3-mediated apoptosis Productive
vIRF3 K10.6 Inhibition of p53 and NF-kB; inhibition of Fas-mediated apoptosis via inhibition CD95L expression Productive
vFLIP K13/ORF71 Transactivator of NF-kB; antiapoptotic activity via FADD and TRADD binding; transformation Latent
vCyclin ORF72
Constitutively activate Cdk6; resistant to Cdk inhibitors, destabilizes p27 Latent
vOX-2 K14 Downregulation of myeloid cell activation; regulation of inflammatory cytokine production (IL-1β, TNF-α, IL-8, IFN-γ, and IL-6) Productive
vGPCR ORF74 Constitutively active; induces VEGF secretion; transformation Latent/productive