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. 2011 Jun 15;11(12):1046–1058. doi: 10.4161/cbt.11.12.15709

Figure 1.

Figure 1

Troglitazone inhibits growth of C4-2 cells. (A) C4-2 cells were treated with DMSO vehicle (Control) or troglitazone (7.5–45 εM) for 6 days. Cells were harvested after 6 days and total cell number was measured using a Z1 Coulter Counter. Each bar represents the mean ± SD of three wells. *p < 0.05 when compared to DMSO control. A representative experiment is shown. (B) C4-2 cells were treated with DMSO vehicle or troglitazone (15–45 εM) for the indicated times. Following treatment total cell number was counted using a Z1 Coulter Counter. Each bar represents the mean ± SD of three wells. *p < 0.05 when compared to DMSO control. A representative experiment is shown. (C) Cells were treated with DMSO vehicle or troglitazone 45 εM for 72 h. The percentage of cells within the different phases of the cell cycle was determined using flow cytometry. *p < 0.05 when compared to control. Each bar represents the mean ± SD of three samples. A representative experiment is shown. (D) C4-2 cells were treated with DMSO vehicle or troglitazone 45 εM for 3 or 6 days. Following treatment, the level of DNA fragmentation (a hallmark of apoptosis) was measured using a Cell Death ELISA. *p < 0.05 when compared to DMSO control. A representative experiment is shown.