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. 2011 Jun 15;11(12):1046–1058. doi: 10.4161/cbt.11.12.15709

Figure 5.

Figure 5

Troglitazone decreases c-Myc mRNA levels and stimulates degradation of c-Myc protein. (A) C4-2 cells were treated with either DMSO vehicle or troglitazone 45 εM for indicated times. The levels of c-Myc and 18S mRNA was then measured by qRT-PCR. Each bar represents the mean ± SD of three samples. The c-Myc/18S RNA ratio for troglitazone is expressed as a percentage of the time matched DMSO control. (B) C4-2 cells were treated with for 48 h DMSO vehicle or troglitazone 45 εM in the presence or absence of the proteasome inhibitor MG132. Following treatment, protein gel blot analysis was used to measure the levels of c-Myc and actin protein in treated cells.