Figure 8.

Informatics analysis of the transcriptional levels of MCT4 in human breast cancers. We used informatics analysis to determine whether the mRNA transcript for MCT4 is commonly upregulated in human breast cancer. (Left) Note that MCT4 (SLC16A3) is overexpressed in all types of breast cancer (relative to normal breast tissue), including both ER(+) and ER(−) cancer sub-types. (Right) In the HER2(+) sub-type, we observed an association with clinical outcome; increased MCT4 transcript levels were associated with decreased overall survival (N = 14 patients).