Table 3.
Rates of gastrointestinal (GI) bleeding according to acid-suppressive medication status.
| Outcome | Acid-Suppressive Medication (n = 45882) |
No Acid-Suppressive Medication (n = 32512) |
Unadjusted Odds Ratio (95% CI) (n = 78394) |
Propensity Matched Odds Ratioa (95% CI) (n = 37966) |
|---|---|---|---|---|
| Nosocomial GI bleeding – no (%) | 153 (0.33) | 71 (0.22) | 1.53 (1.15 – 2.03) | 0.63 (0.42 – 0.93) |
| Clinically-significant GI bleeding – no (%) | 118 (0.26) | 58 (0.18) | 1.44 (1.05 – 1.98) | 0.58 (0.37 – 0.91) |
a
Propensity score incorporated all variables listed in table 1, plus season and admission day of the week. Adjusted odds ratio derived using a GEE model, controlling for all significantly imbalanced baseline characteristics after matching on the propensity score (categorical variables with > 10% incidence and > 3% difference between exposure groups after matching, and continuous variables using a cutoff of p < 0.05): Emergent admission, male, NSAID use, and age.