Table 1.
Clinical and demographic characteristics of type 2 diabetic participants and their relationships with levels of Ang-2 and Tie-2 after controlling for age and BMI
| Parameters | Participants (n = 80) | p- value |
|---|---|---|
| Sex (%) | 47.7 (female) | NS |
| Age (years) | 65 ± 7 | ‡(r = -0.349, p < 0.002) |
| BMI (kg/m2) | 32 ± 6 | †(r = 0.277, p < 0.01) |
| Waist to height ratio | 0.66 ± 0.12 | NS |
| Duration of diabetes (years) | 15 ± 9 | NS |
| *Ang-2 (pg/ml) | 2955 (1349-9000) | ‡(r = 0.355, p < 0.002) |
| sTie-2 (ng/ml) | 28.34 ± 7.58 | †(r = 0.355, p < 0.002) |
| Active smokers (%) | 23 | NS |
| Therapy | †(p < 0.04) | |
| Insulin therapy (%) | 48.7 | |
| Oral anti-diabetic therapy (%) | 51.3 | |
| Systolic blood pressure (mmHg) | 145 ± 21 | NS |
| Diastolic blood pressure (mmHg) | 82 ± 14 | †(r = -0.259, p < 0.02) |
| Diabetic retinopathy (%) | 3.8 | NS |
| Microalbuminuria (%) | 3.8 | NS |
| Polyneuropathy (%) | 50 | †(p < 0.01) |
| #Macro-vascular complications (%) | 29.1 | †(p < 0.009) |
Data are expressed as mean ± standard deviation or as percentage. (*): data not normally distributed, expressed as a median and range, and log10- transformed for analysis. (#): included cardiac, cerebral or peripheral vascular disease. (†): significantly associated with levels of Ang-2. (‡): significantly associated with levels of sTie-2. NS: not significant.