Table 2.
Logistic regression analysis for associations between PLCE1 variant genotypes and SCCHN risk
| Locus | Genotype | Controls (%) | Overall (N = 1,098) | Oropharynx (N = 559) | Non-oropharynx (N = 539) | |||
|---|---|---|---|---|---|---|---|---|
| (N = 1,090) | Cases (%) | OR (95%CI)a | Cases (%) | OR (95%CI)a | Cases (%) | OR (95%CI)a | ||
| PLCE1 rs2274223 | ||||||||
| AA | 504 (46.3) | 477 (43.5) | 1.00 | 253 (45.3) | 1.00 | 224 (41.6) | 1.00 | |
| AG | 474 (43.5) | 506 (46.1) | 1.14 (0.95-1.38) | 248 (44.4) | 1.09 (0.87-1.36) | 258 (48.0) | 1.29 (1.01-1.64) | |
| GG | 111 (10.2) | 114 (10.4) | 1.20 (0.88-1.62) | 58 (10.3) | 1.15 (0.80-1.64) | 56 (10.4) | 1.38 (0.93-2.06) | |
| AG/GG | 585 (53.7) | 620 (56.5) | 1.15 (0.97-1.38) | 306 (54.7) | 1.10 (0.89-1.36) | 314 (58.4) | 1.30 (1.03-1.64) | |
| G allele | 0.320 | 0.335 | ||||||
| PLCE1 rs3203713 | ||||||||
| AA | 759 (70.0) | 753 (68.8) | 1.00 | 391 (70.1) | 1.00 | 362 (67.4) | 1.00 | |
| AG | 298 (27.5) | 311 (28.4) | 1.07 (0.88-1.31) | 146 (26.2) | 0.98 (0.77-1.25) | 165 (30.7) | 1.27 (0.99-1.64) | |
| GG | 27 (2.5) | 31 (2.8) | 1.28 (0.74-2.21) | 21 (3.7) | 1.74 (0.96-3.16) | 10 (1.9) | 0.80 (0.36-1.79) | |
| AG/GG | 325 (30.0) | 342 (31.2) | 1.09 (0.90-1.32) | 167 (29.9) | 1.04 (0.83-1.31) | 175 (32.6) | 1.23 (0.96-1.58) | |
| G allele | 0.162 | 0.170 | ||||||
| PLCE1 rs11599672 | ||||||||
| TT | 519 (48.3) | 554 (50.8) | 1.00 | 270 (48.8) | 1.00 | 284 (52.9) | 1.00 | |
| TG | 473 (44.0) | 469 (43.0) | 0.94 (0.78-1.13) | 246 (44.5) | 1.03 (0.83-1.28) | 223 (41.5) | 0.81 (0.64-1.02) | |
| GG | 82 (7.7) | 67 (6.2) | 0.72 (0.50-1.03) | 37 (6.7) | 0.89 (0.58-1.37) | 30 (5.6) | 0.54 (0.34-0.86) | |
| TG/GG | 555 (51.7) | 536 (49.2) | 0.91 (0.76-1.08) | 283 (51.2) | 1.01 (0.82-1.25) | 253 (47.1) | 0.76 (0.61-0.95) | |
| G allele | 0.297 | 0.277 | ||||||
| Combined effect of risk alleles b | ||||||||
| Trichotomy | 0-1 | 263 (24.6) | 235 (21.6) | 1.00 | 124 (22.5) | 1.00 | 111 (20.8) | 1.00 |
| 2-3 | 607 (56.9) | 630 (58.0) | 1.20 (0.97-1.50) | 320 (58.0) | 1.14 (0.88-1.48) | 310 (58.1) | 1.29 (0.97-1.73) | |
| 4-6 | 197 (18.5) | 221 (20.4) | 1.31 (1.00-1.73) | 108 (19.6) | 1.23 (0.89-1.70) | 113 (21.2) | 1.54 (1.08-2.20) | |
| P trend = 0.046 | P trend = 0.210 | P trend = 0.017 | ||||||
| Dichotomy | 0-1 | 263 (24.6) | 235 (21.6) | 1.00 | 124 (22.5) | 1.00 | 111 (20.8) | 1.00 |
| 2-6 | 804 (75.4) | 851 (78.4) | 1.23 (1.00-1.52) | 428 (77.5) | 1.16 (0.90-1.49) | 423 (79.2) | 1.35 (1.03-1.78) | |
a Adjusted for age, sex, smoking and alcohol status. The SNP calling rates were all >98% with 2 samples failed in rs2274223, 9 samples in rs3203713 and 24 samples in rs11599672.
b The risk alleles: rs2274223G, rs3203713G and rs11599672T.