Table 4.
Stratification analysis for associations between PLCE1 variant genotypes and risk of SCCHN arising at non-oropharyngeal sites
| Variables | rs2274223 (cases/controls) | Adjusted ORa (95%CI) | rs11599672 (cases/controls) | Adjusted ORa (95%CI) | Combined effect of risk alleles b (cases/controls) | Adjusted ORa (95%CI) | |||
|---|---|---|---|---|---|---|---|---|---|
| AA | AG/GG | TT | TG/GG | 0-1 | 2-6 | ||||
| Age, yr | |||||||||
| ≤57(median) | 96/286 | 133/285 | 1.44 (1.02-2.02) | 133/284 | 97/279 | 0.71 (0.50-1.00) | 39/140 | 189/417 | 1.68 (1.09-2.59) |
| >57(median) | 128/218 | 181/300 | 1.19 (0.87-1.63) | 151/235 | 156/276 | 0.88 (0.64-1.20) | 72/123 | 234/387 | 1.18 (0.82-1.70) |
| Gender | |||||||||
| Females | 84/119 | 100/139 | 0.97 (0.64-1.47) | 96/110 | 89/145 | 0.73 (0.48-1.10) | 44/74 | 140/177 | 1.30 (0.81-2.08) |
| Males | 140/385 | 214/446 | 1.51 (1.14-2.00) | 188/409 | 164/410 | 0.84 (0.64-1.10) | 67/189 | 283/627 | 1.41 (1.00-1.98) |
| Smoking status | |||||||||
| Never | 46/236 | 57/298 | 0.99 (0.65-1.53) | 54/266 | 48/261 | 0.85 (0.55-1.31) | 27/116 | 74/407 | 0.81 (0.50-1.33) |
| Ever | 178/268 | 257/287 | 1.33 (1.02-1.72) | 230/253 | 205/294 | 0.73 (0.56-0.94) | 84/147 | 349/397 | 1.65 (1.21-2.26) |
| Alcohol status | |||||||||
| Never | 79/210 | 76/262 | 0.84 (0.57-1.23) | 86/223 | 69/244 | 0.67 (0.46-0.99) | 34/112 | 120/352 | 1.33 (0.83-2.11) |
| Ever | 145/294 | 238/323 | 1.69 (1.25-2.28) | 198/296 | 184/311 | 0.86 (0.64-1.15) | 77/151 | 303/452 | 1.42 (1.00-2.03) |
| Stage | |||||||||
| I-II | 87/504 | 137/585 | 1.40 (1.03-1.91) | 114/519 | 111/555 | 0.84(0.62-1.14) | 44/263 | 178/804 | 1.46 (1.01-2.13) |
| III-IV | 137/504 | 177/585 | 1.24 (0.94-1.65) | 170/519 | 142/555 | 0.78(0.59-1.03) | 67/263 | 245/804 | 1.32 (0.94-1.85) |
a Adjusted for age, sex, smoking and alcohol status (the stratified factor in each stratum excluded).
b The risk alleles: rs2274223G, rs3203713G and rs11599672T.