Table 2.

Top vesicle-associated canonical pathways identified by Ingenuity Pathway Analysis

MPs/MVs			Exosome
Canonical pathway	P value	Ratio	Canonical pathway	P value	Ratio
Actin cytoskeleton signaling	6.05E−14	38/238	Germ cell−Sertoli cell junction signaling	1.20E−23	45/168
Integrin signaling	5.18E−11	32/205	Integrin signaling	1.65E−21	47/205
RhoA signaling	4.53E−09	21/110	Caveolar mediated endocytosis signaling	2.92E−21	30/85
Caveolar mediated endocytosis signaling	1.12E−08	17/85	Virus entry via endocytic pathways	1.58E−20	32/100
Acute phase response signaling	2.21E−08	26/183	Ephrin receptor signaling	2.42E−20	43/199

The P value is calculated using the right-tailed Fisher Exact Test. It is a measure of the likelihood that the association between a set of analyzed molecules and a given pathway is due to random chance. The “ratio” expresses the fraction of molecules fitting a given pathway within an analyzed dataset and the total number of molecules known to be associated with that pathway in Ingenuity’s knowledge base