Table 3.
Frontal white matter | Thalamus | |||||
---|---|---|---|---|---|---|
METH-exposed | Control | P-value* | Meth-exposed | Control | P-value* | |
tCr | 5.78 ± 0.08 | 5.40 ± 0.10 | 0.003 | 6.81 ± 0.13 | 6.89 ± 0.15 | 0.61 |
NA | 7.80 ± 0.09 | 7.48 ± 0.09 | 0.004 | 8.72 ± 0.14 | 8.87 ± 0.18 | 0.56 |
CHO | 2.22 ± 0.06 | 2.07 ± 0.05 | 0.13 | 2.09 ± 0.04 | 2.10 ± 0.05 | 0.67 |
MI | 3.82 ± 0.10 | 3.91 ± 0.10 | 0.92 | 4.25 ± 0.10 | 4.57 ± 0.10 | 0.01 |
GLX | 8.59 ± 0.28 | 7.84 ± 0.17 | 0.02 | 10.71 ± 0.23 | 11.25 ± 0.24 | 0.16 |
NA/tCr | 1.35 ± 0.01 | 1.39 ± 0.02 | 0.30 | 1.29 ± 0.02 | 1.29 ± 0.02 | 0.95 |
CHO/tCr | 0.39 ± 0.01 | 0.38 ± 0.01 | 0.65 | 0.31 ± 0.01 | 0.31 ± 0.01 | 0.78 |
MI/tCr | 0.66 ± 0.02 | 0.73 ± 0.01 | 0.02 | 0.62 ± 0.01 | 0.67 ± 0.02 | 0.03 |
GLX/tCr | 1.49 ± 0.05 | 1.46 ± 0.03 | 0.62 | 1.57 ± 0.03 | 1.65 ± 0.03 | 0.31 |
%GM | 19.2% | 22.9% | 83.3% | 85.4% | ||
Basal ganglia | Frontal gray matter | |||||
METH-exposed | Control | P-value* | METH-exposed | Control | P-value* | |
tCr | 7.47 ± 0.14 | 7.71 ± 0.14 | 0.26 | 6.14 ± 0.07 | 6.08 ± 0.09 | 0.69 |
NA | 7.93 ± 0.11 | 7.84 ± 0.14 | 0.66 | 7.83 ± 0.10 | 7.64 ± 0.12 | 0.30 |
CHO | 1.87 ± 0.05 | 1.89 ± 0.05 | 0.81 | 1.43 ± 0.03 | 1.43 ± 0.03 | 0.77 |
MI | 3.30 ± 0.12 | 3.24 ± 0.11 | 0.62 | 5.03 ± 0.08 | 4.93 ± 0.11 | 0.18 |
GLX | 11.72 ± 0.24 | 12.03 ± 0.31 | 0.42 | 11.17 ± 0.21 | 11.12 ± 0.23 | 0.93 |
NA/tCr | 1.07 ± 0.02 | 1.02 ± 0.01 | 0.07 | 1.28 ± 0.01 | 1.26 ± 0.02 | 0.60 |
CHO/tCr | 0.25 ± 0.01 | 0.25 ± 0.01 | 0.20 | 0.23 ± 0.01 | 0.24 ± 0.01 | 0.60 |
MI/tCr | 0.44 ± 0.02 | 0.42 ± 0.01 | 0.40 | 0.82 ± 0.02 | 0.81 ± 0.01 | 0.24 |
GLX/tCr | 1.58 ± 0.03 | 1.56 ± 0.03 | 0.87 | 1.84 ± 0.04 | 1.84 ± 0.04 | 0.97 |
%GM | 63.9% | 61.2% | 86.3% | 86.8% |
P-values after covarying (ANCOVA) for % gray matter from gray/white segmentation