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. Author manuscript; available in PMC: 2011 Jul 24.
Published in final edited form as: Neuroimage. 2009 Jul 1;48(2):391–397. doi: 10.1016/j.neuroimage.2009.06.062

Table 3.

Brain metabolite concentrations in METH-exposed (n=38, 47.2±1.1 months) and unexposed children (n=37, 46.8±1.3 months) (mean ± SEM)

Frontal white matter Thalamus

METH-exposed Control P-value* Meth-exposed Control P-value*
tCr 5.78 ± 0.08 5.40 ± 0.10 0.003 6.81 ± 0.13 6.89 ± 0.15 0.61
NA 7.80 ± 0.09 7.48 ± 0.09 0.004 8.72 ± 0.14 8.87 ± 0.18 0.56
CHO 2.22 ± 0.06 2.07 ± 0.05 0.13 2.09 ± 0.04 2.10 ± 0.05 0.67
MI 3.82 ± 0.10 3.91 ± 0.10 0.92 4.25 ± 0.10 4.57 ± 0.10 0.01
GLX 8.59 ± 0.28 7.84 ± 0.17 0.02 10.71 ± 0.23 11.25 ± 0.24 0.16
NA/tCr 1.35 ± 0.01 1.39 ± 0.02 0.30 1.29 ± 0.02 1.29 ± 0.02 0.95
CHO/tCr 0.39 ± 0.01 0.38 ± 0.01 0.65 0.31 ± 0.01 0.31 ± 0.01 0.78
MI/tCr 0.66 ± 0.02 0.73 ± 0.01 0.02 0.62 ± 0.01 0.67 ± 0.02 0.03
GLX/tCr 1.49 ± 0.05 1.46 ± 0.03 0.62 1.57 ± 0.03 1.65 ± 0.03 0.31
%GM 19.2% 22.9% 83.3% 85.4%
Basal ganglia Frontal gray matter

METH-exposed Control P-value* METH-exposed Control P-value*

tCr 7.47 ± 0.14 7.71 ± 0.14 0.26 6.14 ± 0.07 6.08 ± 0.09 0.69
NA 7.93 ± 0.11 7.84 ± 0.14 0.66 7.83 ± 0.10 7.64 ± 0.12 0.30
CHO 1.87 ± 0.05 1.89 ± 0.05 0.81 1.43 ± 0.03 1.43 ± 0.03 0.77
MI 3.30 ± 0.12 3.24 ± 0.11 0.62 5.03 ± 0.08 4.93 ± 0.11 0.18
GLX 11.72 ± 0.24 12.03 ± 0.31 0.42 11.17 ± 0.21 11.12 ± 0.23 0.93
NA/tCr 1.07 ± 0.02 1.02 ± 0.01 0.07 1.28 ± 0.01 1.26 ± 0.02 0.60
CHO/tCr 0.25 ± 0.01 0.25 ± 0.01 0.20 0.23 ± 0.01 0.24 ± 0.01 0.60
MI/tCr 0.44 ± 0.02 0.42 ± 0.01 0.40 0.82 ± 0.02 0.81 ± 0.01 0.24
GLX/tCr 1.58 ± 0.03 1.56 ± 0.03 0.87 1.84 ± 0.04 1.84 ± 0.04 0.97
%GM 63.9% 61.2% 86.3% 86.8%
*

P-values after covarying (ANCOVA) for % gray matter from gray/white segmentation