Figure 15.6.

Power of the MCCP algorithm to detect changepoints of different magnitudes, as a function of the number of polarization channels n_p = 8 (A and C) and n_p = 16 (B and D) and the number of photons in the interval. Top row, solid lines, and symbols: The fraction of changepoints detected versus an arbitrary relative photon rate change of χ and various N. Dotted lines: The fraction of changepoints that were detected and assigned a time lying within the ${\widehat{\mathcal{L}}}_{\text{r}}^{\ast }-2$ confidence interval of the true time. The high fraction meeting this condition indicates that these confidence intervals are conservative. Bottom row: The fraction of changepoints detected for an angle change corresponding to the tilting motion of a probe attached to the myosin V lever as it steps (see Table 15.2), as a function of signal-to-background ratios (SBR) for various N.