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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Brain Behav Immun. 2011 Apr 3;25(6):1223–1232. doi: 10.1016/j.bbi.2011.03.016

Figure 5.

Figure 5

LPS and morphine in vitro stimulated release of IL-1β from splenic leukocytes differed between wild-type strains. Lines represent logistic fitted dose-response curve.

Panel A: LPS stimulation yielded clear dose-response curves with similar EC50 values but different efficacies between strains. C57BL/6 mice displayed the highest maximal response, whilst CBA the least, and Balb/c mice were in-between.

Panel B: Morphine stimulation did not induce IL-1β expression except at 100 μM. C57BL/6 mice displayed the highest response, whilst CBA the least, and Balb/c mice were in-between.