Table 2.

Variation of f_sec, f_dis and Median Evolution Rates for Tissue-Specific Genes From 27 Human Tissues, Sorted by Median K_A/K_S

Tissue	Gene number	fsec (%)	fdis (%)	Median KA/KS	Median KA	Median KS	Median KA/KS nonsecreted	Median KA/KS secreted	ft (%) (gene number)
Fetal brain	382	20.7	5.0	0.040	0.022	0.526	0.038	0.052	ND
Amygdala	350	25.1	7.4	0.041	0.024	0.553	0.036	0.058	60.5 (104)
Uterus	128	32.0	14.1	0.061	0.036	0.595	0.044	0.081	29.3 (22)
Hep3b	371	16.4	8.4	0.063	0.036	0.532	0.056	0.100	ND
Spinal cord	150	36.7	14.0	0.069	0.042	0.575	0.053	0.103	ND
Heart	250	24.0	17.2	0.070	0.051	0.685	0.049	0.141	31.8 (49)
Salivary gland	164	36.0	11.0	0.071	0.046	0.684	0.057	0.099	17.2 (15)
Ovary	123	44.7	21.1	0.071	0.044	0.595	0.054	0.094	14.5 (11)
Prostate	112	30.4	8.0	0.075	0.052	0.601	0.061	0.100	7.1 (4)
Placenta	231	39.4	14.7	0.075	0.057	0.689	0.064	0.114	21.5 (26)
Thyroid	97	35.1	16.5	0.076	0.044	0.566	0.070	0.133	ND
Pancreas	350	36.6	14.0	0.077	0.055	0.644	0.063	0.107	ND
DOHH2	340	16.8	8.5	0.078	0.045	0.554	0.073	0.100	ND
Pituitary gland	133	35.3	12.0	0.083	0.047	0.553	0.076	0.098	ND
THY-	194	20.1	11.3	0.083	0.052	0.564	0.071	0.160	ND
DRG	131	37.4	14.5	0.085	0.048	0.565	0.060	0.098	40.9 (29)
HUVEC	216	25.5	9.7	0.085	0.052	0.554	0.082	0.101	ND
Spleen	293	32.1	12.0	0.087	0.066	0.732	0.067	0.158	24.0 (43)
Adrenal gland	132	25.8	17.4	0.091	0.060	0.607	0.083	0.131	24.7 (20)
Trachea	78	50.0	14.1	0.100	0.068	0.704	0.070	0.225	22.7 (10)
Whole blood	332	29.2	10.2	0.101	0.066	0.646	0.078	0.224	ND
Lung	119	46.2	21.9	0.101	0.086	0.715	0.082	0.156	29.4 (20)
Kidney	171	34.5	26.3	0.102	0.064	0.629	0.091	0.120	47.3 (53)
Testis	287	12.2	6.3	0.103	0.057	0.530	0.097	0.122	48.0 (59)
Liver	314	42.0	33.1	0.114	0.083	0.652	0.086	0.164	54.0 (115)
Fetal liver	214	45.8	38.8	0.126	0.086	0.636	0.088	0.177	ND
Thymus	121	40.5	9.1	0.127	0.082	0.622	0.067	0.241	46.8 (36)

Strong correlations exist between f_dis and both f_sec (r = 0.601, P = 2 × 10^-3) and median K_A/K_S values (r = 0.531, P = 4 × 10^-3), and also between f_sec and median K_a/K_S values (r = 0.415, P = 3 × 10^-2). Abbreviations: DOHH2, follicular lymphoma; Hep3b, hepatocellular carcinoma; HUVEC, human umbilical vein endothelial cells; THY^-, CD34⁺Thy^- progenitor cells (GCSF treated patients); DRG, dorsal root ganglia; f_sec, the fraction of predicted secreted gene products; f_dis, the fraction of disease genes; f_T, the fraction of human genes that are specific to a tissue, whose mouse ortholog is also specific to that tissue; ND, not determined.