Table 4. Cox proportional hazards multivariate models.
| Variable | HR | 95% CI | P |
|---|---|---|---|
| Locoregional recurrence | |||
| Grade 3 | 1.938 | 0.823–4.568 | 0.130 |
| Size>20 mm | 0.861 | 0.408–1.817 | 0.694 |
| LN+ | 2.188 | 1.054–4.542 | 0.036 |
| LVI | 1.286 | 0.546–3.026 | 0.564 |
| EIC+ | 3.136 | 1.328–7.405 | 0.009 |
| Subtype | |||
| Modified LA (reference) | 1.0 | ||
| Modified LB | 2.483 | 0.982–6.281 | 0.055 |
| Basal | 3.939 | 1.281–12.114 | 0.017 |
| HER2 | 1.931 | 0.382–9.754 | 0.426 |
| Unclassified | 4.471 | 0.926–21.59 | 0.062 |
| Resolved model | |||
| EIC+ | 2.476 | 1.070–5.730 | 0.034 |
| Modified LB | 3.612 | 1.555–8.340 | 0.003 |
| Basal | 5.541 | 2.279–13.47 | <0.001 |
| HER2 | 3.549 | 0.764–16.51 | 0.106 |
| Unclassified | 4.913 | 1.077–22.42 | 0.040 |
| Distant metastasis free survival | |||
| Grade 3 | 1.100 | 0.529–2.287 | 0.879 |
| Size>20 mm | 1.372 | 0.742–2.540 | 0.313 |
| LN+ | 3.822 | 2.036–7.175 | <0.001 |
| LVI | 1.832 | 0.960–3.499 | 0.067 |
| Subtype | |||
| Modified LA (reference) | 1.0 | ||
| Modified LB | 2.872 | 1.326–6.222 | 0.007 |
| Basal | 3.273 | 1.139–9.396 | 0.028 |
| HER2 | 1.825 | 0.386–8.639 | 0.448 |
| Unclassified | 9.902 | 3.269–29.99 | <0.001 |
| Resolved model | |||
| LN+ | 4.013 | 2.154–7.477 | <0.001 |
| LVI | 2.011 | 1.075–3.764 | 0.029 |
| Modified LB | 3.023 | 1.501–6.089 | 0.002 |
| Basal | 3.902 | 1.657–9.191 | 0.002 |
| HER2 | 2.064 | 0.472–9.026 | 0.336 |
| Unclassified | 10.87 | 3.882–30.461 | <0.001 |
| Breast cancer specific death | |||
| Grade 3 | 1.307 | 0.570–2.997 | 0.527 |
| Size>20 mm | 1.879 | 0.927–3.807 | 0.080 |
| LN+ | 4.535 | 2.153–9.553 | <0.001 |
| LVI | 2.085 | 1.030–4.223 | 0.041 |
| Subtype | |||
| Modified LA (ref) | 1.0 | ||
| Modified LB | 3.084 | 1.280–7.431 | 0.012 |
| Basal | 3.780 | 1.155–12.37 | 0.028 |
| HER2 | 2.095 | 0.412–10.65 | 0.373 |
| Unclassified | 8.167 | 1.997–33.40 | 0.003 |
| Resolved model | |||
| LN+ | 4.906 | 2.353–10.22 | <0.001 |
| LVI | 2.518 | 1.267–5.004 | 0.008 |
| Modified LB | 3.617 | 1.629–8.031 | 0.002 |
| Basal | 5.715 | 2.173–15.03 | <0.001 |
| HER2 | 2.907 | 0.641–13.17 | 0.166 |
| Unclassified | 10.37 | 2.801–38.42 | <0.001 |
Abbreviations: CI=confidence interval; EIC+ =extensive intraduct component of DCIS=ductal carcinoma in situ; HR=hazard ratio; LA=luminal A; LB=luminal B; LN=lymph node; LVI=lymphatic vascular invasion.
Bold typescript indicates statistical significance.