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. 2004 Jan 1;18(1):88–98. doi: 10.1101/gad.285404

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Figure 2. — Liver failure in Apc2^Δ/^flox Mx-Cre mice. (A) Survival curve of adult Apc2^Δ/^flox Mx-Cre and control mice (Apc2^Δ/^flox and Apc2^flox^/+ Mx-Cre mice) after two injections of 400 μg of pI/C. Most mice died between day 11 and day 14 after the first pI/C injection. (B) Southern blot analysis of Apc2^Δ/^flox or Apc2^Δ/^flox Mx-Cre livers; (np) no phenotype, (p) with phenotype. (C) Western blot analysis of Apc2^Δ/^flox and Apc2^Δ/^flox Mx-Cre livers after pI/C injection for Apc2-protein levels. Actin is the loading control; (np) no phenotype, (p) phenotype. (D) Squashes from Apc2^Δ/^flox Mx-Cre livers. Seventy-three percent of mitotic cells were in a prometaphase-like state with condensed chromosomes. (E) Hematoxylin/eosin staining of livers from Apc2^Δ/^flox and Apc2^Δ/^flox Mx-Cre mice. Apc2^Δ/^flox Mx-Cre hepatocytes appeared larger and had condensed chromosomes.