Table 1.
Gene sequences of patients with hepatitis C infection and hepatocellular carcinoma compared to gene sequences of subjects with hepatitis C infection and without hepatocellular carcinoma, GenBank, NCBI, (N=279). Odds ratios and p-values were calculated using logistic regression while controlling for Japanese origin.
| HCC Sequence Set (N=65) (%) | Control Sequence Set (N=214)(%) | Individual Analysis | Multivariable Analysis | |||
|---|---|---|---|---|---|---|
| OR (95%CI) | p-value | OR (95% CI) | p-value | |||
| Gene Position | ||||||
| 36C/G | 3(5) | 3(2) | 8.38 (1.28, 54.62) | 0.026 | 14.79 (2.01,108.35) | 0.008 |
| 36A | 62(95) | 211(98) | ||||
| 78U | 2(3) | 43(20) | 0.16 (0.03, 0.71) | 0.016 | ||
| 78C | 63(96) | 171(80) | ||||
| 209A | 37(56) | 74(35) | 2.93 (1.57, 5.42) | <0.001 | 13.50 (4.48, 40.68) | <0.001 |
| 209G | 28(43) | 140(65) | ||||
| 271U/C | 42(65) | 61(29) | 3.84 (1.91, 7.70) | <0.001 | 10.57 (3.42, 32.66) | <0.001 |
| 271A | 23(35) | 153(71) | ||||
| 309C/A | 29(45) | 55(26) | 2.04 (1.05, 3.98) | 0.034 | 2.66 (1.17, 6.05) | 0.018 |
| 309U | 36(55) | 159(74) | ||||
| 384U | 3(5) | 1(1) | 12.70 (1.07,149.80) | 0.043 | ||
| 384C | 62(95) | 213(99) | ||||
| 408U | 4(6) | 2(1) | 9.98 (1.38, 72.12) | 0.023 | ||
| 408C | 61(94) | 212(99) | ||||
| 435A/C | 23(35) | 27(13) | 2.12 (1.05, 4.26) | 0.035 | 4.09 (1.73, 9.68) | 0.001 |
| 435G | 42(65) | 187(87) | ||||
| 465U | 5(8) | 4(2) | 4.93 (1.07, 22.64) | 0.040 | ||
| 465C | 60(92) | 210(98) | ||||
| 481A | 13(20) | 8(4) | 3.47 (1.31, 9.13) | 0.012 | 3.825 (1.2, 11.89) | 0.02 |
| 481G | 52(80) | 206(96) | ||||
| 546A/C | 8(12) | 9(4) | 3.85 (1.16, 12.80) | 0.027 | 10.04 (2.17, 46.37) | 0.003 |
| 546G | 57(88) | 205(96) | ||||
| 209A/271U/C | 0.16 (0.03, 0.72) | 0.01 | ||||