Fig. 1.

Effect of topical spinal administration of ketanserin (1, 10 and 100 μg/50 μl) on the a. electrical b. mechanical punctate and c. thermal evoked responses of wide dynamic range dorsal horn neurones. Ketanserin significantly inhibited the noxious mechanical (26 and 60 g) and heat (45–48 °C) evoked neuronal responses, evoked responses of wide dynamic range dorsal horn neurones. Data expressed as mean ± SEM. Significance at the lower dose of 10 μg/μl is denoted by +, whereas significance at the higher dose of 100 μg/μl is denoted by *p < 0.05.