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Effect of topical spinal administration of DOI (3.6 and 17.8 μg/50 μl) on a. electrical b. mechanical punctate and c. thermal evoked responses of wide dynamic range dorsal horn neurones. DOI significantly increased the evoked response to mechanical (26 and 60 g) and heat (48 °C) stimuli. Data expressed as mean ± SEM. Significance is denoted by *p < 0.05.
