Table 2.
Relative Risk (RR) for AMI, Non-Fatal, and Fatal AMI According to History of Gout, Stratified by Gender
| Females
|
Males
|
P value for Interaction by Gender | |||||||
|---|---|---|---|---|---|---|---|---|---|
| No. of AMI | Incidence (/1000 PY) | Crude RR (95% CI) | Multivariate RR* (95% CI) | No. of AMI | Incidence (/1000 PY) | Crude RR (95% CI) | Multivariate RR* (95% CI) | ||
| All AMI | |||||||||
| No Gout | 752 | 6.03 | 1.0 (referent) | 1.0 (referent) | 1,837 | 10.34 | 1.0 (referent) | 1.0 (referent) | 0.003 |
| Gout | 244 | 10.04 | 1.67 (1.45, 1.93) | 1.39 (1.20, 1.61) | 435 | 12.23 | 1.19 (1.07, 1.32) | 1.11 (0.99, 1.23) | |
|
|
|
|
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| Non-Fatal AMI | |||||||||
| No Gout | 552 | 4.42 | 1.0 (referent) | 1.0 (referent) | 1,420 | 7.99 | 1.0 (referent) | 1.0 (referent) | 0.005 |
| Gout | 183 | 7.53 | 1.71 (1.44, 2.02) | 1.41 (1.19, 1.67) | 335 | 9.42 | 1.18 (1.05, 1.33) | 1.11 (0.98, 1.25) | |
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|
|
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| Fatal AMI | |||||||||
| No Gout | 200 | 1.60 | 1.0 (referent) | 1.0 (referent) | 417 | 2.35 | 1.0 (referent) | 1.0 (referent) | 0.30 |
| Gout | 61 | 2.51 | 1.57 (1.18, 2.09) | 1.33 (0.99, 1.78) | 100 | 2.81 | 1.19 (0.96, 1.49) | 1.10 (0.88, 1.38) | |
RR = relative risk; 95% CI = 95% confidence interval; PY = person-years
*
Multivariate models were adjusted for age (continuous), baseline history of co-morbid medical condition [hypertension, diabetes, hyperlipidemia, and chronic obstructive pulmonary disease] (yes, no), baseline Charlson comorbidity score (continuous), and monthly prescription medication use [NSAID, diuretic, statin, anticoagulant, aspirin, hormone replacement therapy, and glucocorticoid] (yes, no) as time-varying covariates.