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. 2010 Dec 7;1(2):155–167.

Figure 5.

Figure 5

Histological analysis of brain tumors arising in Nestin-TVA mice injected with viruses expressing KRas, Tet-off and TRE-Akt. H&E stained 5 μm brain histology sections from: A. a typical glioma in the brain of an untreated 24 days old mouse; B. a tumor from a mouse treated with doxycycline for 24 hours; C. a resistant tumor from a 57 day old mouse treated with doxycycline for 36 days (corresponds to the MRI shown in Figure 4C); D. a relapsed tumor from a 122 day old mouse 11 days after doxycycline withdrawal; E. a relapsed tumor from a 141 day old mouse 30 days after doxycycline withdrawal. F-J. IHC for the HA epi-tope tag on virally delivered Akt and hema-toxylin counterstain corresponding to the tumors shown in (A-E). Scale bar represents 200 μm.