Figure 5. Selective proteolysis of radiolabeled wild type IFABP.
After hydrophobic photolabeling with 125I-TID-PC, apo-IFABP was blotted and subjected to selective proteolisys with BNPS-Skatole. The results showed a preferential radiolabeling (right panel) of the fragment containing the α-helical region (9.6 kDa) than the one corresponding to the second half of the β-barrel (5.5 kDa) compared to the coomasie blue staining (left panel).