Skip to main content
. Author manuscript; available in PMC: 2012 Jun 26.
Published in final edited form as: Circ Res. 2011 May 12;109(1):71–79. doi: 10.1161/CIRCRESAHA.111.246512

Figure 7.

Figure 7

Purkinje EADs and underlying mechanism. (A) At CL=4000ms with complete IKr block, EADs develop starting from beat #127 (top panel). Simulated tracings of INaL2, INaL3 and ICaL (bottom panel) identify reactivations of INaL2 as the mechanism of EAD generation. (B) 80% block of Ito1 and 50% block of IKr lead to increased EAD activity due to elevation of plateau potential. EADs are observed starting from beat #18 and persist from beat #42. (C) Two consecutive APs (beats #41 and #42 in (B)) are overlaid with INaL2 and ICaL. A portion of beat #42 (box in left panel) is enlarged in the right panel. Reactivated INaL2 is of much larger amplitude than ICaL and precedes the reactivation of ICaL and the EAD upstroke.