Table 4.

Senna

Authors	Study Group+ type	Methods+ Key Outcomes
Berg (1983) [71]	44 children with soiling (mean age 7.9 years) Study type 2b All given toileting advice.	RCT: senna vs. placebo vs. no treatment. Results: All groups improved from baseline (p < 0.05). Senna no more effective than placebo/no treatment.
Perkin (1977) [53]- Study described in the 'Lactulose section' - table
Sondheimer et al (1982) [72]	37 children Study type: 2b	Methods: Non-blinded RCT Senna vs. mineral oil for 3 months Results: Faecal soiling + decreased stool frequency) significantly better in mineral-oil group. At least 1 recurrence of symptoms occurred in 66% of mineral-oil-treated and 89% of Senna-treated patients.
Connolly et al (1974) [56] -Study described in the 'Lactulose section' - table