Table 1.
Summary of statistical analyses for 4 dependent measures. Each dependent variable was analyzed in a Cage Familiarity (CAGE) by Time of Cage Introduction (INTRO) by Hour of Testing (HOUR) by Drug Treatment (DRUG) ANOVA with repeated measures on the first 3 factors.
| Visits to Home Base from | |||||||||||||
| Distance Traveled | Duration of Staying in Cage | Exits from Cage | Phase 1 | ||||||||||
| Source | df | Mean Square | F | Sig. | Mean Square | F | Sig. | Mean Square | F | Sig. | Mean Square | F | Sig. |
| Within-Subjects Contrasts | |||||||||||||
| INTRO | 1 | 2224908867 | 22.9 | 0.000 | 16232863 | 79.8 | 0.000 | 3317 | 8.9 | 0.007 | 19320 | 24.6 | 0.000 |
| INTRO * DRUG | 1 | 1839965205 | 19.0 | 0.000 | 588913 | 2.9 | 0.103 | 3468 | 9.3 | 0.006 | 16725 | 21.3 | 0.000 |
| Error(INTRO) | 22 | 97033892 | 203487 | 373 | 784 | ||||||||
| CAGE | 1 | 17701171788 | 375.4 | 0.000 | 169590106 | 419.9 | 0.000 | 4720 | 8.1 | 0.009 | 141484 | 33.0 | 0.000 |
| CAGE * DRUG | 1 | 17751213019 | 376.4 | 0.000 | 6113519 | 15.1 | 0.001 | 2228 | 3.8 | 0.063 | 137281 | 32.0 | 0.000 |
| Error(CAGE) | 22 | 47154899 | 403928 | 581 | 4289 | ||||||||
| HOUR | 1 | 237500968 | 2.7 | 0.115 | 23543456 | 100.6 | 0.000 | 5355 | 12.4 | 0.002 | 1151 | 2.2 | 0.153 |
| HOUR * DRUG | 1 | 21492295 | 0.2 | 0.627 | 531418 | 2.3 | 0.146 | 7203 | 16.7 | 0.000 | 7 | 0.0 | 0.911 |
| Error(HOUR) | 22 | 88224156 | 234028 | 431 | 526 | ||||||||
| INTRO * CAGE | 1 | 931631085 | 15.2 | 0.001 | 13760369 | 64.5 | 0.000 | 893 | 4.0 | 0.059 | 7033 | 5.4 | 0.029 |
| INTRO * CAGE * DRUG | 1 | 735495405 | 12.0 | 0.002 | 306872 | 1.4 | 0.243 | 721 | 3.2 | 0.087 | 7057 | 5.5 | 0.029 |
| Error(INTRO*CAGE) | 22 | 61156552 | 213365 | 225 | 1293 | ||||||||
| INTRO * HOUR | 1 | 2609009790 | 29.3 | 0.000 | 21625057 | 225.4 | 0.000 | 30 | 0.3 | 0.610 | 29800 | 31.4 | 0.000 |
| INTRO * HOUR * DRUG | 1 | 4087487232 | 45.9 | 0.000 | 1798563 | 18.7 | 0.000 | 609 | 5.4 | 0.029 | 31468 | 33.1 | 0.000 |
| Error(INTRO*HOUR) | 22 | 89134994 | 95927 | 112 | 950 | ||||||||
| CAGE * HOUR | 1 | 3303732675 | 57.1 | 0.000 | 23390748 | 104.8 | 0.000 | 2961 | 12.4 | 0.002 | 33867 | 25.1 | 0.000 |
| CAGE * HOUR * DRUG | 1 | 3331266987 | 57.6 | 0.000 | 327649 | 1.5 | 0.238 | 2523 | 10.5 | 0.004 | 33602 | 24.9 | 0.000 |
| Error(CAGE*HOUR) | 22 | 57815111 | 223114 | 240 | 1348 | ||||||||
| INTRO * CAGE * HOUR | 1 | 4645326525 | 153.7 | 0.000 | 19868514 | 195.9 | 0.000 | 363 | 3.0 | 0.099 | 17710 | 40.9 | 0.000 |
| INTRO * CAGE * HOUR * | |||||||||||||
| DRUG | 1 | 4897187026 | 162.1 | 0.000 | 1727200 | 17.0 | 0.000 | 1764 | 14.4 | 0.001 | 17749 | 41.0 | 0.000 |
| Error(INTRO*CAGE*HOUR) | 22 | 30215914 | 101397 | 123 | 433 | ||||||||
| Between-Subjects Effects | |||||||||||||
| DRUG | 1 | 73038969284 | 146.9 | 0.000 | 7882396 | 20.3 | 0.000 | 13635 | 17.2 | 0.000 | 509438 | 61.9 | 0.000 |
| Error | 22 | 497327329 | 387476 | 791 | 8236 | ||||||||