Figure 7.
Photographic and histological features of the hindlimb in AIA treated with 15d-PGJ2 or PBS. (a and c) Samples from a representative rat treated with 15d-PGJ2 in AIA. (b and d) Samples from a PBS-treated rat in AIA. Joint swelling of the foot in AIA was clearly reduced with 15d-PGJ2 administration at a dose of 1 mg/kg/d, at day 18 (a), compared with control (b). H&E staining of the foot joint also revealed a marked decrease of synovial inflammatory cell infiltrate and synovial lining hyperplasia (c). In contrast, hindlimbs treated with PBS revealed typical features of arthritis such as massive inflammatory cell infiltrate, pannus, and bone destruction (d). Similar findings of photographic and histological features were observed in all rats of each group. (c) ×25; (d) ×50.