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. 2011 Jul 25;6(7):e22091. doi: 10.1371/journal.pone.0022091

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Zhao et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Four guinea pigs were intranasally inoculated with 10^4.0 PFU of virus and each animal was housed in a separate cage. At 24 h p.i., a naïve guinea pig was placed in the same cage with each inoculated guinea pig. Virus titers in nasal washes were plotted as a function of time post-inoculation. Titers of intranasally inoculated animals are represented by dashed lines and solid squares; virus titers of exposed guinea pigs are shown with solid lines and solid triangles. The limit of virus detection was 10 PFU/mL.