Table 2. Direct contact transmission of wild-type and rH1N1-pBJ09 reassortant viruses in guinea pigs.
| Inoculated animals | Contact animals | ||||
| Virus | No. with virus detection (peak titer)a | No. with seroconversion (HI titer range)b | No. with virus detection (peak titer)a | No. with seroconversion (HI titer range)b | Transmission |
| pBJ09 | 4/4 (6.5±0.4) | 4/4 (320) | 4/4 (5.5±0.3) | 4/4 (160–320) | Efficient |
| rH1N1 | 4/4 (4.7±0.4) | 4/4 (40–80) | 0/4 | 0/4 | None |
| pBJ09HANA:rH1N1 | 4/4 (5.9±0.6) | 4/4 (160–320) | 4/4 (5.8±0.8) | 4/4 (80–320) | Efficient |
| rH1N1HANA:pBJ09 | 4/4 (5.3±0.2) | 4/4 (80–160) | 1/4 (3.1) | 1/4 (40) | Inefficient |
| pBJ09HA: rH1N1 | 4/4 (4.4±0.4) | 4/4 (80–160) | 3/4 (3.8±0.7) | 3/4 (40–80) | Inefficient |
| pBJ09NA: rH1N1 | 4/4 (5.0±0.3) | 4/4 (80) | 0/4 | 0/4 | None |
| pBJ09PB2: rH1N1 | 4/4 (4.0±0.3) | 4/4 (40–80) | 0/4 | 0/4 | None |
| pBJ09PB1: rH1N1 | 4/4 (4.8±0.4) | 4/4 (80) | 0/4 | 0/4 | None |
| pBJ09PA:rH1N1 | 4/4 (5.0±0.5) | 4/4 (80) | 0/4 | 0/4 | None |
| pBJ09NP: rH1N1 | 4/4 (4.4±0.2) | 4/4 (40) | 0/4 | 0/4 | None |
| pBJ09M: rH1N1 | 4/4 (5.3±0.5) | 4/4 (40–80) | 0/4 | 0/4 | None |
| pBJ09NS: rH1N1 | 4/4 (6.0±0.6) | 4/4 (40–80) | 2/4 (4.6±0.2) | 2/4 (40–80) | Inefficient |
a
Number of the infected guinea pigs/total number of the guinea pigs (mean peak titer log10PFU/mL ± standard deviation).
b
Serum was collected on day 18 p.i. and seroconversion was confirmed by hemagglutination inhibition (HI) assay.