Figure 2. Lymphoma onset and progression are accelerated by Separase reduction.

Double mutant (ESPL1^+/hyp,p53^−/−) animals developed severe lymphomas with a median latency of 118 days and within 200 days all animals developed full blown lymphomas (red line). In p53^−/− animals (blue line), lymphomas were detected significantly later (p<0.0001) with a median onset of 151 days and progression of lymphomas was significantly slower, measured by sick appearance of the mice and subsequent histopathological analysis. The ESPL1^+/hyp, p53^+/− mice (yellow line) do not develop lymphomas but develop other phenotypes over a longer period of time.