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(A) PIBO and IPPA are colored according to circularly permuted fragments. N-terminal and C-terminal fragments are colored red and green respectively. The side chains of the conserved glutamate (Glu 371 and Glu 197) of the GxHxxE motif are shown as ball-and-stick models. (B) Structural comparison between PIBO (green) and IPPA (red), shown in a stereo view.
