Figure 7. Bone erosion and histological parameters of arthritis are reduced in mice over-expressing C17.

One hind paw per animal was harvested at the time of euthanasia and was analyzed by micro-CT and subsequent histology. (A) Representative histology images from individual hind paws are shown either stained with H&E (top row) or stained with Safranin O (bottom row). Images were taken at 10× magnification. (B) Scoring of disease severity according to diverse histological parameters. (C) Representive micro-CT scans are shown. Red box highlights prominent joint erosion in paw of GFP treated mouse. Similar data were generated in at least three independent experiments with at least five animals per group.